hsa-miR-297

ncRNA information

ncRNA name

hsa-miR-297

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MRP-2

Cancer information

Cancer name

Colorectal Carcinoma

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

27

Male patients

13

Female patients

14

Age range and number

10(<60)+17(>=60)

Research information

PMID

Description

We found that ectopic expression of miR-297 inMDRcolorectal carcinoma cells reduced MRP-2 protein level and sensitized these cells to anticancer drugs in vitro and in vivo.

Tissue resource

human colorectal cancer and their corresponding non-tumorous samples

human ilepithelial ovarian carcinomaecal colorectal adenocarcinoma cell lines HCT-8

human colorectal cancer cell lines HCT-116

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Putuo District Center Hospital

the Cell Bank of the Chinese Academy of Sciences

Country

China

Continent

Asia