Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-297
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
MRP-2
Cancer name
Colorectal Carcinoma
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
27
Male patients
13
Female patients
14
Age range and number
10(<60)+17(>=60)
PMID
Description
We found that ectopic expression of miR-297 inMDRcolorectal carcinoma cells reduced MRP-2 protein level and sensitized these cells to anticancer drugs in vitro and in vivo.
Tissue resource
human colorectal cancer and their corresponding non-tumorous samples
human ilepithelial ovarian carcinomaecal colorectal adenocarcinoma cell lines HCT-8
human colorectal cancer cell lines HCT-116
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Putuo District Center Hospital
the Cell Bank of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.