Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-222
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ADAM-17
Cancer name
Colorectal Carcinoma
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Oxaliplatin/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We found that elevated levels of miR-222 in the mimics-transfected HCT116/L-OHP and HCT-8/VCR cells reduced the ADAM-17 protein level and the luciferase activity of an ADAM-17 3' untranslated region-based reporter and sensitized these cells' apoptosis to some anticancer drugs.
Tissue resource
human ilepithelial ovarian carcinomaecal colorectal adenocarcinoma cell lines HCT-8
human colorectal carcinoma cell lines HCT-116
human colorectal carcinoma vincristine-resistant cell lines HCT-8/VCR
human colorectal carcinoma oxaliplatin-resistant cell lines HCT-116/L-OHP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Cell Bank of Chinese Academy of Science
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.