hsa-miR-222

ncRNA information

ncRNA name

hsa-miR-222

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ADAM-17

Cancer information

Cancer name

Colorectal Carcinoma

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin/Vincristine

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

We found that elevated levels of miR-222 in the mimics-transfected HCT116/L-OHP and HCT-8/VCR cells reduced the ADAM-17 protein level and the luciferase activity of an ADAM-17 3' untranslated region-based reporter and sensitized these cells' apoptosis to some anticancer drugs.

Tissue resource

human ilepithelial ovarian carcinomaecal colorectal adenocarcinoma cell lines HCT-8

human colorectal carcinoma cell lines HCT-116

human colorectal carcinoma vincristine-resistant cell lines HCT-8/VCR

human colorectal carcinoma oxaliplatin-resistant cell lines HCT-116/L-OHP

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Cell Bank of Chinese Academy of Science

Country

China

Continent

Asia