Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Upregulation of miR-221 induces the malignant phenotype of human osteosarcoma whereas knockdown of miR 221 reverses this phenotype.
Tissue resource
human osteosarcoma tissues and normal adjacent tissues
human osteosarcoma cell lines SOSP-9607
human osteosarcoma cell lines SOSP-9901
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Institute of Chinese PLA of Tangdu Hospital
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.