CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-21

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN/PI3K/Akt signaling pathway

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

23466500

Description

MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN.

Tissue resource

human gastric adenocarcinoma cell lines SGC7901

human gastric adenocarcinoma cisplatin resistant cell lines SGC7901/DDP

Experiment

qRT-PCR,Western blot

Institute

KeyGEN Biotech

Country

China

Continent

Asia