hsa-miR-135a

ncRNA information

ncRNA name

hsa-miR-135a

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MCL1

Cancer information

Cancer name

Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

In vitro drug sensitivity assay demonstrated that overexpression of miR-135a/b sensitized A549/CDDP cells to cisplatin.

Tissue resource

human lung cancer cell lines A549

human lung cancer drug-resistant cell lines A549/CDDP

human lung cancer cell lines A549

human lung cancer drug-resistant cell lines A549/CDDP

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

Biosis Biotechnology Company

Country

China

Continent

Asia