hsa-miR-106a

ncRNA information

ncRNA name

hsa-miR-106a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

BCL10/caspase-7/ZEB1

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Modulation of these microRNAs resensitizes PTX-resistant cancer cells by targeting BCL10, caspase-7, and ZEB1.

Tissue resource

ovarian serous tumours tissues

human ovarian carcinoma cell line SKOV3

human ovarian carcinoma paclitaxel-resistant sublines SKpac-8

human ovarian carcinoma paclitaxel-resistant sublines SKpac-10

human ovarian carcinoma paclitaxel-resistant sublines SKpac-11

human ovarian carcinoma paclitaxel-resistant sublines SKpac-12

human ovarian carcinoma paclitaxel-resistant sublines SKpac-16

human ovarian carcinoma paclitaxel-resistant sublines SKpac-17

ovarian serous tumours tissues

human ovarian carcinoma cell line SKOV3

human ovarian carcinoma paclitaxel-resistant sublines SKpac-8

human ovarian carcinoma paclitaxel-resistant sublines SKpac-10

human ovarian carcinoma paclitaxel-resistant sublines SKpac-11

human ovarian carcinoma paclitaxel-resistant sublines SKpac-12

human ovarian carcinoma paclitaxel-resistant sublines SKpac-16

human ovarian carcinoma paclitaxel-resistant sublines SKpac-17

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

College of Medicine, CHA University

College of Medicine, CHA University

Country

South Korea

South Korea

Continent

Asia

Asia