Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-487a
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
BCRP/ABCG2
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Mitoxantrone
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our results suggested that miR-487a can directly regulate BCRP expression and reverse chemotherapeutic drug resistance in a subset of breast cancers.
Tissue resource
human breast cancer cell lines MCF-7
human breast cancer mitoxantrone-resistant cell lines MCF-7/MX
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
American Type Culture Collection
National Cancer Institute, National Institutes of Health
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.