Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-106a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Mcl-1
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-106a inhibited cell survival and cisplatin resistance through downregulating the expression of Mcl-1.
Tissue resource
ovarian cancer cisplatin-sensitive cell lines A2780
ovarian cancer cisplatin-resistant cell lines A2780/DDP
Experiment
qRT-PCR,Western blot
Institute
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.