CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-223

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

ABCB1

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

Liver

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin/5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

23925649

Description

The over-expression of miR-223 increased the HCC cell sensitivity to anticancer drugs, and the inhibition of miR-223 had the opposite effect.

Tissue resource

hepatocellular carcinoma cell lines BEL-7402

hepatocellular carcinoma cell lines Hep3B

hepatocellular carcinoma cell lines HepG2

hepatocellular carcinoma cell lines HCC3

hepatocellular carcinoma cell lines Huh-7

hepatocellular carcinoma cell lines LM-6

hepatocellular carcinoma cell lines SMMC7721

hepatocellular carcinoma cell lines SK-Hep-1

Experiment

qRT-PCR,Western blot

Institute

Country

Continent