hsa-miR-199a

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

mTOR

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Description

The study concludes that miR-199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mTOR and that mTOR may be the target of miR-199a during this process.

Tissue resource

cisplatin-resistant ovarian cancer cell line C13*

cisplatin-sensitive ovarian cancer cell line OV2008

Experiment

qRT-PCR,Western blot

Country

Continent