Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-134
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
MAGI2
Cancer name
Lung Adenocarcinoma
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Gefitinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Whereas knockdown of these miRNAs inhibited the EMT process and reversed TGF-b1-induced resistance to gefitinib.
Tissue resource
lung adenocarcinoma cell lines A549
lung adenocarcinoma cell lines LC2/ad
lung adenocarcinoma cell lines PC3
lung adenocarcinoma cell lines PC9
lung adenocarcinoma cell lines RERF-LCKJ
lung adenocarcinoma cell lines RERF-LCMS
lung adenocarcinoma cell lines PC14
lung adenocarcinoma cell lines ABC-1
lung adenocarcinoma cell lines A549
lung adenocarcinoma cell lines LC2/ad
lung adenocarcinoma cell lines PC3
lung adenocarcinoma cell lines PC9
lung adenocarcinoma cell lines RERF-LCKJ
lung adenocarcinoma cell lines RERF-LCMS
lung adenocarcinoma cell lines PC14
lung adenocarcinoma cell lines ABC-1
lung adenocarcinoma cell lines A549
lung adenocarcinoma cell lines LC2/ad
lung adenocarcinoma cell lines PC3
lung adenocarcinoma cell lines PC9
lung adenocarcinoma cell lines RERF-LCKJ
lung adenocarcinoma cell lines RERF-LCMS
lung adenocarcinoma cell lines PC14
lung adenocarcinoma cell lines ABC-1
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
RIKEN Cell Bank
Country
Continent
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.