hsa-miR-221

ncRNA information

ncRNA name

hsa-miR-221

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis/Treatment

Upstream regulatory factors

Not available

Downstream target

PTEN

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Trastuzumab

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

These findings indicate that miR-221 may promote trastuzumab resistance and metastasis of HER2-positive breast cancers by targeting PTEN.

Tissue resource

breast cancer samples

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Xijing Hospital affiliated to the Fourth Military Medical University

Country

China

Continent

Asia