hsa-miR-21

ncRNA information

ncRNA name

hsa-miR-21

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN/PDCD4

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

EGFR-TKI

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-21 is involved in acquired resistance of EGFR-TKI in NSCLC, which is mediated by downregulating PTEN and PDCD4 and activating PI3K/Akt pathway.

Tissue resource

human lung adenocarcinoma cell lines PC9

human lung adenocarcinoma gefitinib-resistance cell lines PC9R

Experiment

qRT-PCR,Western blot


Institute

Country

Continent