hsa-miR-27a

ncRNA information

ncRNA name

hsa-miR-27a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

SLC7A11

Cancer information

Cancer name

Bladder Cancer

Cancer site

Bladder

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-27a was found to target the cystine/glutamate exchanger SLC7A11 and to contribute to cisplatin resistance through modulation of glutathione biosynthesis.

Tissue resource

bladder cancer cell lines EJ/T24

bladder cancer cell lines RT112

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

American Type Culture Collection

Country

USA

Continent

Amercia