hsa-miR-125b

ncRNA information

ncRNA name

hsa-miR-125b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis

Upstream regulatory factors

Not available

Downstream target

GRK2/PUMA

Cancer information

Cancer name

Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Daunorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

46

Male patients

26

Female patients

20

Age range and number

Not available

Research information

PMID

Description

MicroRNA-125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis.

Tissue resource

bone marrow samples

leukemia cell lines K562

leukemia cell lines THP-1

leukemia cell lines Jurkat

leukemia cell lines REH

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Shanghai Jiaotong University Affiliated Shanghai First People's Hospital

Cell Bank of Type Culture Collection of the Chinese Academy of Sciences

Country

China

Continent

Asia