Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-125b
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
GRK2/PUMA
Cancer name
Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Daunorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
46
Male patients
26
Female patients
20
Age range and number
Not available
PMID
Description
MicroRNA-125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis.
Tissue resource
bone marrow samples
leukemia cell lines K562
leukemia cell lines THP-1
leukemia cell lines Jurkat
leukemia cell lines REH
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Shanghai Jiaotong University Affiliated Shanghai First People's Hospital
Cell Bank of Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.