hsa-miR-221

ncRNA information

ncRNA name

hsa-miR-221

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

PI3K/Akt signaling pathway

Cancer information

Cancer name

Glioblastoma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Carmustine

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Further investigation revealed that miR-221 down-regulated PTEN and activated Akt,which resulted in cell survival andBCNU resistance.

Tissue resource

human glioblastomas cell lines U87

human glioblastomas cell lines U251

human glioma cell lines SWOZ1

human glioma carmustine-resistant cell lines SWOZ2-BCNU

Experiment

qRT-PCR,Western blot


Institute

Country

Continent