hsa-miR-34a

ncRNA information

ncRNA name

hsa-miR-34a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MET

Cancer information

Cancer name

Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Gefitinib

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET.

Tissue resource

lung cancer cell lines HCC827

lung cancer cell lines MRC-5

lung cancer cell lines PC-9

Experiment

qRT-PCR,Dual-luciferase reporter assay


Institute

Type Culture Collection of Chinese Academy of Sciences

Shanghai Pulmonary Hospital

Country

China

Continent

Asia