hsa-miR-128

ncRNA information

ncRNA name

hsa-miR-128

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

ABCC5

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Overexpression of miR-128 resensitized SKOV3/CP cells to cisplatin, whereas miR-128 inhibitors increased cisplatin resistance in SKOV3 cells.

Tissue resource

human epithelial ovarian cancer cell lines SKOV3

human epithelial ovarian cancer cell lines OVCAR3

human epithelial ovarian cancer cell lines PEO14

human epithelial ovarian cancer cisplatin-resistant cell lines SKOV3/CP

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Country

USA

Continent

Amercia