Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-136
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Epithelial Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Enforced expression of miR-136 decreased the chemoresistance to cisplatin in OVC cells through inhibition of cell survival.
Tissue resource
epithelial ovarian carcinoma tissue samples
ovarian cancer cisplatin-resistant parental cell lines C13
ovarian cancer cisplatin-resistant parental cell lines A2780CP
ovarian cancer cisplatin-sensitive cell lines OV2008
ovarian cancer cisplatin-sensitive cell lines A2780S
Experiment
qRT-PCR,Western blot
Institute
Dalian Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.