hsa-miR-542-3p

ncRNA information

ncRNA name

hsa-miR-542-3p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PI3K-Akt signaling pathway

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Trastuzumab

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiRNA-542-3p downregulation promotes trastuzumab resistance in breast cancer cells via AKT activation.

Tissue resource

breast cancer cell lines SKBR3

breast cancer cell lines MCF7/HER2

Experiment

qRT-PCR,Western blot


Institute

the Type Culture Collection of the Chinese Academy of Sciences

Country

China

Continent

Asia