hsa-miR-10a

ncRNA information

ncRNA name

hsa-miR-10a

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

TGF-Ī²/Smad2/STAT3/STAT5

Cancer information

Cancer name

Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-Ī²/Smad2/STAT3/STAT5 pathway.

Tissue resource

human lung cancer cell lines A549

human lung cancer cell lines A549/DDP

Experiment

qRT-PCR,Western blot


Institute

the Cell Bank of Chinese Academy of Science

Country

China

Continent

Asia