hsa-miR-381

ncRNA information

ncRNA name

hsa-miR-381

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

NEFL

Cancer information

Cancer name

Glioblastoma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Either suppressing miR-381 or enforcing NEFL expression dramatically sensitized glioblastoma cells to temozolomide.

Tissue resource

human astrocytoma samples and normal brain tissues

human glioblatoma cell lines U251

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Xiangya Hospital

Country

China

Continent

Asia