hsa-miR-15b

ncRNA information

ncRNA name

hsa-miR-15b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PEBP4

Cancer information

Cancer name

Lung Adenocarcinoma

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our results suggest that upregulation of miR-15b could suppress PEBP4 expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin.

Tissue resource

lung adenocarcinoma tissues

lung adenocarcinoma cell lines A549

Experiment

qRT-PCR,Western blot


Institute

Yinzhou People's Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia