hsa-miR-320a

ncRNA information

ncRNA name

hsa-miR-320a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

ARPP-19/ERRĪ³

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Tamoxifen

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

58

Male patients

31

Female patients

27

Age range and number

Not available

Research information

PMID

25736597

Description

MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRĪ³.

Tissue resource

breast cancer and normal breast samples

human breast carcinoma cell lines MCF-7

human breast carcinoma cell lines T47D

Experiment

qRT-PCR,Western blot,Luciferase reporter assay

Institute

the First Affiliated Hospital of Anhui Medical University

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia

Institutes for Systems Genetics, West China Hospital
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