Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-197
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
NLK
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our work first demonstrated that miR-197 can confer drug resistance to Taxol, by regulating tumor suppressor, NLK expression in ovarian cancer cells.
Tissue resource
human ovarian cancer cell lines A2780
human ovarian cancer cell lines SKOV3
human ovarian cancer cell lines A2780/Tax
normal ovarian epithelial cell lines IOSE386
normal ovarian epithelial cell lines IOSE397
Experiment
qRT-PCR,Western blot
Institute
Country
Continent
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.