hsa-miR-197

ncRNA information

ncRNA name

hsa-miR-197

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

NLK

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our work first demonstrated that miR-197 can confer drug resistance to Taxol, by regulating tumor suppressor, NLK expression in ovarian cancer cells.

Tissue resource

human ovarian cancer cell lines A2780

human ovarian cancer cell lines SKOV3

human ovarian cancer cell lines A2780/Tax

normal ovarian epithelial cell lines IOSE386

normal ovarian epithelial cell lines IOSE397

Experiment

qRT-PCR,Western blot


Institute

Country

Continent