HOTTIP

ncRNA information

ncRNA name

HOTTIP

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

HOXA13

Cancer information

Cancer name

Pancreatic Cancer

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

90

Male patients

57

Female patients

33

Age range and number

46(<60)+44(>=60)

Research information

PMID

Description

The long noncoding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer.

Tissue resource

corresponding pancreatic cancer tissues and the paired non-tumor tissues

human pancreatic cancer cell lines PANC-1

human pancreatic cancer cell lines MIA

human pancreatic cancer cell lines PaCa-2

human pancreatic cancer cell lines Capan-2

human pancreatic cancer cell lines SW1990

human pancreatic cancer cell lines BxPC-3

Experiment

qRT-PCR,Western blot


Institute

Sun Yat-Sen Memorial Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia