Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTTIP
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
HOXA13
Cancer name
Pancreatic Cancer
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
90
Male patients
57
Female patients
33
Age range and number
46(<60)+44(>=60)
PMID
Description
The long noncoding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer.
Tissue resource
corresponding pancreatic cancer tissues and the paired non-tumor tissues
human pancreatic cancer cell lines PANC-1
human pancreatic cancer cell lines MIA
human pancreatic cancer cell lines PaCa-2
human pancreatic cancer cell lines Capan-2
human pancreatic cancer cell lines SW1990
human pancreatic cancer cell lines BxPC-3
Experiment
qRT-PCR,Western blot
Institute
Sun Yat-Sen Memorial Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.