hsa-miR-125b

ncRNA information

ncRNA name

hsa-miR-125b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Mcl-1

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-125b is negatively correlated with DOX resistance in breast cancer cells.

Tissue resource

normal breast epithelial cell lines MCF-10A

breast cancer cell lines MDA-MB-435

breast cancer cell lines T-47D

breast cancer cell lines MCF-7

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Country

China

Continent

Asia