Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-148b
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
DNMT1
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNMT1 expression.
Tissue resource
human lung adenocarcinoma cell lines A549
human lung adenocarcinoma cell lines SPC-A1
human lung adenocarcinoma cisplatin-resistant cell lines A549/DDP
human lung adenocarcinoma cisplatin-resistant cell lines PC-A1/DDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Academy of Military Medical Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.