hsa-miR-494

ncRNA information

ncRNA name

hsa-miR-494

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

PTEN

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

Liver

Treatment information

Treatment type

Chemotherapy

Drug

Sorafenib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN.

Tissue resource

paired human hepatocellular carcinoma and adjacent non-tumoral liver tissues

human hepatocellular carcinoma cell lines Huh-7

human hepatocellular carcinoma cell lines HepG2

normal humanhepatocyte cell lines HL-7702

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

First Hospital, Jilin University

the Institute of Cell Biology of the Chinese Academy of Science

Country

China

Continent

Asia