ncRNA name
hsa-miR-10b
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
HDAC4
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Over-expression of miR-10b in ER-positive MCF-7 and T47D cells led to increased resistance to tamoxifen.
Tissue resource
breast cancer cell lines MCF-7
breast cancer cell lines T47D
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
American Type Culture Collection
Country
USA
Continent
Amercia