hsa-miR-134

ncRNA information

ncRNA name

hsa-miR-134

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Pak2

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Over-expression of miR-134 enhanced the sensitivity of SKOV3-TR30 cells to paclitaxel, and increased paclitaxel-induced apoptosis.

Tissue resource

ovarian cancer tissue samples

ovarian carcinoma cell lines SKOV3

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Shengjing Hospital of China Medical University

Tumor Cell Bank Research Institute of the Chinese Academy of Medical Sciences

Country

China

Continent

Asia