Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-31
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
KCNMA1
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Over-expression of miR-31 increased resistance, as did knockdown of KCNMA1 or inhibition of BK channels.
Tissue resource
human ovarian adenocarcinoma cell lines A2780
human ovarian adenocarcinoma cisplatin-resistant cell lines MCP1
human ovarian adenocarcinoma cisplatin-resistant cell lines CP70
Experiment
qRT-PCR,Western blot
Institute
Imperial College London
Country
UK
Continent
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.