hsa-miR-21

ncRNA information

ncRNA name

hsa-miR-21

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Trastuzumab

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-21 confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patient.

Tissue resource

HER2-negative breast cancer tissues

breast cancer cell lines SKBR3

Experiment

qRT-PCR,Western blot


Institute

Universitat Autònoma de Barcelona

American Type Culture Collection

Country

Spain

USA

Continent

Europe

Amercia