Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-16
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
BCL-2
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The mimics of miR-16 greatly decreased the sensitivity of U251MG/TR cells to temozolomide.
Tissue resource
human glioblastoma cell lines U-138MG
human glioblastoma cell lines A172
human glioblastoma cell lines LN382
human glioblastoma cell lines AM-38
human glioblastoma cell lines U-251MG
human glioblastoma cell lines KMG4
Experiment
qRT-PCR,Western blot
Institute
American Type Culture Collection
Biofavor company
Country
USA
China
Continent
Amercia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.