hsa-miR-101-3p

ncRNA information

ncRNA name

hsa-miR-101-3p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

RRM1

Cancer information

Cancer name

Pancreatic Ductal Adenocarcinoma

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer.

Tissue resource

pancreatic ductal adenocarcinoma tissues

human pancreatic ductal adenocarcinoma cell lines AsPC-1

human pancreatic ductal adenocarcinoma cell lines PANC-1

human pancreatic ductal adenocarcinoma cell lines MIA-PaCa2

human pancreatic ductal adenocarcinoma cell lines BxPC-3

primary cell line ASAN-PaCa

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

the University of Heidelberg

American Type Culture Collection

European Pancreas Center

Country

Germany

USA

Continent

Europe

Amercia

Europe