Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-101-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
RRM1
Cancer name
Pancreatic Ductal Adenocarcinoma
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer.
Tissue resource
pancreatic ductal adenocarcinoma tissues
human pancreatic ductal adenocarcinoma cell lines AsPC-1
human pancreatic ductal adenocarcinoma cell lines PANC-1
human pancreatic ductal adenocarcinoma cell lines MIA-PaCa2
human pancreatic ductal adenocarcinoma cell lines BxPC-3
primary cell line ASAN-PaCa
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the University of Heidelberg
American Type Culture Collection
European Pancreas Center
Country
Germany
USA
Continent
Europe
Amercia
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.