Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-145
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
MRP1
Cancer name
Gallbladder Cancer
Cancer site
Gallbladder
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Studies on GBC cell lines suggested an increased cisplatin efficacy with miR-145 overexpression, whereas decreasing miR-145 expression reduced cisplatin sensitivity.
Tissue resource
fresh gallbladder cancer tissues and the corresponding noncancerous gallbladder tissues
human embryonic kidney cell lines HEK-293T
human gallbladder cancer cell lines of GBC-SD
human gallbladder cancer cell lines of SGC-996
Experiment
qRT-PCR,Western blot
Institute
Renji Hospital
American Type Culture Collection
the Academy of Life Sciences, Tongji University
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.