CTRR-ncRNA

ncRNA information

ncRNA name

hsa_circ_0004674

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-342-3p/FBN1

Cancer information

Cancer name

Osteosarcoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

18

Male patients

23

Female patients

25(<25)+16(>=25)

Age range and number

Not available

Research information

PMID

34407841

Description

Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis

Tissue resource

primary osteosarcoma tissues

human osteosarcoma cell lines U2OS

human osteosarcoma cell lines KHOS

Experiment

41

Institute

Jingmen No.1 People’s Hospital

Biovector

Country

China

Continent

Asia