Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINK-A
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Lymphoma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Ibrutinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Inhibition of LINK-A lncRNA overcomes ibrutinib resistance in mantle cell lymphoma by regulating Akt/Bcl2 pathway
Tissue resource
Ibrutinib-resistant mantle cell lymphoma cell lines MAVER-1
Ibrutinib-resistant mantle cell lymphoma cell lines granta-519
Ibrutinib-intermediated mantle cell lymphoma cell lines Mino
Ibrutinib-intermediated mantle cell lymphoma cell lines REC-1
Ibrutinib-sensitive mantle cell lymphoma cell lines Jeko-1
Experiment
None
Institute
American Type Culture Collection
Country
United States
Continent
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.