hsa-miR-138

ncRNA information

ncRNA name

hsa-miR-138

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Bcl-2

Cancer information

Cancer name

Glioblastoma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-138 overexpression increased TMZ resistance in long-term glioblastoma cell lines and glioma initiating cell cultures.

Tissue resource

tissue samples from primary and recurrent glioblastomas

human long-term glioma cell lines LN-18

human long-term glioma cell lines LN-229

human long-term glioma cell lines LN-308

human long-term glioma cell lines LN-319

human long-term glioma cell lines LN-428

human long-term glioma cell lines D247MG

human long-term glioma cell lines A172

human long-term glioma cell lines U87MG

human long-term glioma cell lines T98G

Experiment

qRT-PCR,Luciferase reporter assay


Institute

tumor tissue bank of the Department of Neuropathology, Heinrich Heine University

Lausanne

Country

Germany

Switzerland

Continent

Europe

Europe