Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-138
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Bcl-2
Cancer name
Glioblastoma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-138 overexpression increased TMZ resistance in long-term glioblastoma cell lines and glioma initiating cell cultures.
Tissue resource
tissue samples from primary and recurrent glioblastomas
human long-term glioma cell lines LN-18
human long-term glioma cell lines LN-229
human long-term glioma cell lines LN-308
human long-term glioma cell lines LN-319
human long-term glioma cell lines LN-428
human long-term glioma cell lines D247MG
human long-term glioma cell lines A172
human long-term glioma cell lines U87MG
human long-term glioma cell lines T98G
Experiment
qRT-PCR,Luciferase reporter assay
Institute
tumor tissue bank of the Department of Neuropathology, Heinrich Heine University
Lausanne
Country
Germany
Switzerland
Continent
Europe
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.