hsa-miR-223

ncRNA information

ncRNA name

hsa-miR-223

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

IGF1R/PI3K/Akt signaling pathway

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Egfr-Tkis

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-223 is a potential therapeutic target for overcoming EGFR-TKIs resistance.

Tissue resource

human lung cancer cell lines HCC827

human lung cancer cell lines PC9

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

American Type Culture Collection

the Xinqiao Hospital, Third Military Medical University

Country

USA

China

Continent

Amercia

Asia