Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-223
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
IGF1R/PI3K/Akt signaling pathway
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Egfr-Tkis
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-223 is a potential therapeutic target for overcoming EGFR-TKIs resistance.
Tissue resource
human lung cancer cell lines HCC827
human lung cancer cell lines PC9
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
American Type Culture Collection
the Xinqiao Hospital, Third Military Medical University
Country
USA
China
Continent
Amercia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.