Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-518a-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PIK3C2A
Cancer name
Gastrointestinal Stromal Tumor
Cancer site
Stomach, Small Intestine
Treatment type
Chemotherapy
Drug
Imatinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
20
Male patients
15
Female patients
5
Age range and number
Not available
PMID
Description
Low expression of miR-518a-5p is likely to upregulate PIK3C2A and affect the cellular response to the drug, causing resistance to imatinib in GISTs.
Tissue resource
gastrointestinal stromal tumors matched-pair specimens
human embryonic kidney cell lines HEK-293T
human gastrointestinal stromal tumors cell lines GIST882
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Zhongshan Hospital, Fudan University
Clontech
Brigham and Women's Hospital, Harvard Medical School
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.