Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-421
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
HIF-1Ī±
Downstream target
E-cadherin/caspase-3
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-421 regulated by HIF-1Ī± promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.
Tissue resource
gastric cancer cell lines AGS
gastric cancer cell lines SGC-7901
gastric cancer cell lines NCI-N87
gastric cancer cell lines HGC-27
human embryonic kidney cell lines HEK-293T
gastric cancer cell lines MKN-28
gastric cancer cell lines MKN-45
gastric cancer cell lines SNU-16
immortalized human gastric epithelial cell lines GES-1
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Cell Bank of Type Culture Collection of Chinese Academy of Sciences
3DBiopharm Biotech Co. Ltd.
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.