hsa-miR-421

ncRNA information

ncRNA name

hsa-miR-421

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis

Upstream regulatory factors

HIF-1Ī±

Downstream target

E-cadherin/caspase-3

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MicroRNA-421 regulated by HIF-1Ī± promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.

Tissue resource

gastric cancer cell lines AGS

gastric cancer cell lines SGC-7901

gastric cancer cell lines NCI-N87

gastric cancer cell lines HGC-27

human embryonic kidney cell lines HEK-293T

gastric cancer cell lines MKN-28

gastric cancer cell lines MKN-45

gastric cancer cell lines SNU-16

immortalized human gastric epithelial cell lines GES-1

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Cell Bank of Type Culture Collection of Chinese Academy of Sciences

3DBiopharm Biotech Co. Ltd.

Country

China

Continent

Asia