Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
miR-204-5p
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
90
Male patients
49
Female patients
41
Age range and number
48(<60)+42(>=60)
PMID
Description
LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.
Tissue resource
human primary colorectal cancer tissues and their paired adjacent noncancerous tissues
human embryonic kidney cell lines HEK-293T
colorectal cancer cell lines HCT8
colorectal cancer cell lines HCT116
colorectal cancer cell lines HT29
colorectal cancer cell lines LoVo
colorectal cancer cell lines SW480
Experiment
qRT-PCR,Western blot,Northern blot,Luciferase reporter assay
Institute
Fudan University Shanghai Cancer Center and the Affiliated Hospital of Jiangnan University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.