hsa-miR-34a-5p

ncRNA information

ncRNA name

hsa-miR-34a-5p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Diagnosis/Treatment

Upstream regulatory factors

Not available

Downstream target

CD17

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Carboplatin/Cisplatin/Doxorubicin/Etoposide/Methotrexate

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene.

Tissue resource

osteosarcoma cell lines G-292

osteosarcoma cell lines SJSA-1

osteosarcoma cell lines MG63

osteosarcoma cell lines Saos-2

osteosarcoma cell lines U2OS

osteosarcoma cell lines MNNG/HOS

osteosarcoma cell lines MG63.2

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

University of Chicago

Country

USA

Continent

Amercia