Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-34a-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
CD17
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Carboplatin/Cisplatin/Doxorubicin/Etoposide/Methotrexate
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene.
Tissue resource
osteosarcoma cell lines G-292
osteosarcoma cell lines SJSA-1
osteosarcoma cell lines MG63
osteosarcoma cell lines Saos-2
osteosarcoma cell lines U2OS
osteosarcoma cell lines MNNG/HOS
osteosarcoma cell lines MG63.2
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
University of Chicago
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.