hsa-miR-320a

ncRNA information

ncRNA name

hsa-miR-320a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

PDCD4

Cancer information

Cancer name

Pancreatic Cancer

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our study demonstrated that miR-320a played important role in regulating 5-FU resistance by targeting PDCD4 and might be developed as new therapeutic target for pancreatic cancer.

Tissue resource

human pancreatic cancer cell lines PANC-1

human pancreatic cancer cell lines PATU8988

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Peking Union Medical College

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia