hsa-miR-18a

ncRNA information

ncRNA name

hsa-miR-18a

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Dicer

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells.

Tissue resource

triple-negative breast cancer cancerous and the corresponding paired normal adjacent tissue

human triple-negative breast cancer cell lines MDAMB-231

human triple-negative breast cancer cell lines MDA-MB-468

Experiment

qRT-PCR,Western blot


Institute

the Affiliated Hospital of Qingdao University

the Cell Bank of the Chinese Academy of Sciences

Country

China

Continent

Asia