Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-205
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
VEGFA/FGF2
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Doxorubicin/Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Overexpression of miR-205 restores drug sensitivity by promoting apoptosis in breast cancer cells.
Tissue resource
breast cancer tissues
human breast cancer cell lines MCF-7
human breast cancer MDR-counterpart cell lines MCF-7/A02
human leukemia cell lines K562
human leukemia cell lines HL60
human leukemia cell lines BJAB
Experiment
qRT-PCR,Western blot
Institute
Tianjin Medical University Cancer Institute and Hospital
Institute of Hematology
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.