Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-644a
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
CTBP1/p53
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Re-activation of the miR-644a/CTBP1/p53 may represent a new strategy for overcoming both therapy resistance and metastasis.
Tissue resource
human breast cancer cell lines MDA-MB-231
human breast cancer cell lines MCF-7
human breast cancer cell lines BT474
human breast cancer cell lines SK-BR-3
human breast cancer cell lines ZR-75-1
normal breast epithelial cell lines MCF-10A
normal breast epithelial cell lines MCF-12A
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
American Type Culture Collection
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.