Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
ABCG2
Cancer name
Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Alisertib/Bortezomib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
36
Male patients
17
Female patients
19
Age range and number
Not available
PMID
Description
Overexpression of lncRNA NEAT1 mitigates multidrug resistance by inhibiting ABCG2 in leukemia.
Tissue resource
peripheral white blood cell from patients
chronic myelogenous leukemia cell lines K562
Experiment
qRT-PCR,Western blot
Institute
Weihai Maternal and Child Health Hospital
Jinan CN-Cell Biotechnology, Co, Ltd.
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.