Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-145
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
MRP1
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our study revealed miR-145 sensitizes breast cancer to doxorubicin by targeting MRP1.
Tissue resource
breast cancer samples
breast cancer cell lines MCF-7
breast cancer cell lines MDA-MB-453
breast cancer cell lines MDA-MB-468
breast cancer cell lines MCF-10A
breast cancer cell lines MDA-kb2
breast cancer adriamycin-resistant cell lines MCF-7/ADR
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Wuxi Maternity and Children Health Hospital
the cell bank of Shanghai Institute for Biological Sciences
FuDan Cell Center
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.